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目的 :左炔诺孕酮宫内释放系统对IGF-1的影响及预防盆腔炎疗效分析。方法 :选取2014年1月~2015年11月在我院住院治疗的子宫内膜息肉患者130例,根据术后治疗药物随机分为左炔诺孕酮宫内释放系统治疗组(观察组)和去氧孕烯炔雌醇片治疗组(对照组),比较两组患者治疗前后月经量和子宫内膜厚度、子宫内膜IGF-1表达、以及盆腔炎发生率的差异。分析盆腔炎发生与子宫内膜IGF-1表达的关系,分析子宫内膜厚度与子宫内膜IGF-1表达的关系。结果 :治疗后观察组患者的月经量(33.57±15.62)ml、子宫内膜厚度(6.12±0.85)mm均低于对照组(52.85±15.39)ml和(8.52±0.91)mm,且差异均具有统计学差异;治疗后观察组患者的腺皮质和间质IGF-1表达(1.41±0.74)和(1.36±0.72)均低于对照组(1.75±0.82)和(1.72±0.83),且差异均具有统计学差异;观察组盆腔炎的发生率(6例,9.23%)低于对照组(17例,26.15%),且差异具有统计学差异;治疗后发生盆腔炎的患者腺皮质和间质IGF-1表达(1.58±0.81)和(1.62±0.75)均高于未发生盆腔炎者(1.22±0.71)和(1.32±0.75),且差异均具有统计学差异;子宫内膜厚度与腺皮质IGF-1表达呈正相关,与间质IGF-1表达呈正相关。结论 :左炔诺孕酮宫内释放系统能明显减少子宫内膜息肉患者术后盆腔炎的发生率好改善其临床症状,可能因为药物抑制了子宫内膜增生和IGF-1表达从而减少盆腔炎的发生。
OBJECTIVE: To investigate the effect of levonorgestrel-releasing system on IGF-1 and the prevention of pelvic inflammatory disease. Methods: A total of 130 patients with endometrial polyps who were hospitalized in our hospital from January 2014 to November 2015 were randomly divided into levonorgestrel-treated intrauterine release system (observation group) and (Control group). The differences of menstrual flow, endometrial thickness, endometrial IGF-1 expression and the incidence of pelvic inflammatory disease between the two groups before and after treatment were compared. To analyze the relationship between the occurrence of pelvic inflammatory disease and endometrial IGF-1 expression and to analyze the relationship between endometrial thickness and endometrial IGF-1 expression. Results: After treatment, the menstrual flow in the observation group (33.57 ± 15.62) ml and the endometrial thickness (6.12 ± 0.85) mm were lower than those in the control group (52.85 ± 15.39) ml and (8.52 ± 0.91) mm, respectively (1.41 ± 0.74) and (1.36 ± 0.72) in the observation group were significantly lower than those in the control group (1.75 ± 0.82) and (1.72 ± 0.83), respectively, and the differences were statistically significant (6 cases, 9.23%) were lower than the control group (17 cases, 26.15%), and the difference was statistically significant; after treatment, the incidence of pelvic inflammatory disease in patients with glandular cortex and interstitial (1.58 ± 0.81) and (1.62 ± 0.75) were significantly higher than those without pelvic inflammatory disease (1.22 ± 0.71) and (1.32 ± 0.75), respectively, and the difference was statistically significant. The relationship between endometrial thickness and glandular cortex IGF-1 expression was positively correlated with the expression of interstitial IGF-1 was positively correlated. Conclusion: Levonorgestrel intrauterine release system can significantly reduce the incidence of postoperative pelvic inflammatory disease in patients with endometrial polyps to improve its clinical symptoms may be due to drugs inhibit endometrial hyperplasia and IGF-1 expression thereby reducing pelvic inflammatory disease happened.