Experimentation data of perspex glass sheet cutting, using CO2 laser, with missing values were modelled with semi-supervised artificial neural networks. Factorial design of experiment was selected for the verification of orthogonal array based model prediction. It shows improvement in modelling of edge quality and kerf width by applying semi-supervised learning algorithm, based on novel error assessment on simulations. The results are expected to depict better prediction on average by utilizing the systematic randomized techniques to initialize the neural network weights and increase the number of initialization. Missing values handling is difficult with statistical tools and supervised learning techniques; on the other hand, semi-supervised learning generates better results with the smallest datasets even with missing values. Experimentation data of perspex glass sheet cutting, using CO2 laser, with missing values ​​were modeled with semi-supervised artificial neural networks. Factorial design of experiment was selected for the verification of orthogonal array based model prediction. It shows improvement in modeling of edge quality and kerf width by applying semi-supervised learning algorithm, based on novel systematic assessment of simulations. The results are expected to depict better prediction on average by utilizing the systematic randomized techniques to initialize the neural network weights and increase the number of initialization. Missing values ​​handling is difficult with statistical tools and supervised learning techniques; on the other hand, semi-supervised learning generating better with the smallest datasets even with missing values.