老年性黄斑变性(简称SMD)是美国60岁以上老年人最主要的致盲原因。据Klein等人报告,1971～1974年期间SMD的患病率为:白种男人:9.6%;白种女人:6.9%;黑种男人:9.3%;黑种女人:11.4%。眼底镜下本病的特点是有玻璃膜疣(drusen)存在。临床研究证实玻璃膜疣与黄斑盘状变性,与视网膜色素上皮萎缩以及与脉络膜新生血管膜形成有关。组织病理学的研究业已证明玻璃膜疣与SMD有关,有玻璃膜疣的患者容易发生SMD。要了解及治疗SMD这一复杂的疾患必须熟悉由于年龄增加所引起的视网膜色素上皮及Bruch膜的自然变化,了解drusen的类型及形成,以及从脉络膜向色素上皮下间隙长入新生血 Age-related macular degeneration (referred to as SMD) is the United States over the age of 60 the most important cause of blindness. According to Klein et al., The prevalence of SMD between 1971 and 1974 was: Caucasian men: 9.6%; Caucasian women: 6.9%; Black men: 9.3%; Black women: 11.4%. Under the fundus This disease is characterized by the presence of drusen. Clinical studies confirm the drusen degeneration and macular degeneration, and retinal pigment epithelium atrophy and choroidal neovascularization related. Histopathology studies have shown that drusen is associated with SMD and that patients with drusen are prone to SMD. To understand and treat the complex condition of SMD, we must be familiar with the natural changes of the retinal pigment epithelium and Bruch’s membrane caused by aging, understand the type and formation of drusen, and grow new blood from the choroid to the subepithelial space