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免疫抑制剂和Ｔ细胞去除虽然可以明显降低移植物抗宿主病 (ＧＶＨＤ)的发生 ,但存在继发感染、白血病和其它恶性肿瘤高复发的问题。如何改良Ｔ细胞 ,提高异基因骨髓移植(ａｌｌｏ ＢＭＴ)效果成为引人注目的问题。我们采用体外诱导的Ｔｈ2细胞进行ａｌｌｏ ＢＭＴ ,探讨该种Ｔ?
Although immunosuppressive agents and T cell depletion can significantly reduce the incidence of graft-versus-host disease (GVHD), there is a problem of secondary infection, high recurrence of leukemia and other malignancies. How to improve T cells and improve allogeneic bone marrow transplantation (allo BMT) effect has become a conspicuous problem. We use in vitro induced Th2 cells for allo BMT, to explore the kind of T?