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从乙型肝炎患者血清中检测白细胞介素—6(IL—6)、肿瘤坏死因子(TNF—α)活性水平,同时测定谷丙转氨酶(GPT)和IgG含量,结果显示重症肝炎(SH)、慢性活动性肝炎(CAH)和肝炎后肝硬化(HC)患者IL—6、TNF—α活性水平显著高于正常对照组(NC)(P<0.01),以SH为最高,SH>CAH>HC,慢性迁延性肝炎(CPH)患者无明显变化(P>0.05)。另外,在SH、CAH组中,IL—6活性水平与TNF—α活性水平,以及IL—6、TNF—α活性水平与血清IgG、GPT含量均呈正相关。
The level of IL-6 and TNF-α in sera from patients with hepatitis B were detected, and the contents of alanine aminotransferase (GPT) and IgG were measured simultaneously. The results showed severe hepatitis (SH) The levels of IL-6 and TNF-α in chronic active hepatitis (CAH) and posthepatitic cirrhosis (HC) patients were significantly higher than those in normal control group (P <0.01), SH was the highest, SH> CAH> HC , Chronic persistent hepatitis (CPH) patients did not change significantly (P> 0.05). In addition, the level of IL-6 activity in SH and CAH groups was positively correlated with the level of TNF-α, the levels of IL-6 and TNF-α, and the levels of IgG and GPT in serum.