论文部分内容阅读
血小板活化因子(PAF)发现于70年代初。Benvenist等人发现嗜碱性粒细胞在受到IgE刺激后释放一种物质引起血小板聚集与脱颗粒,此为迄今最强的引起血小板聚集的物质,因而将其命名为PAF。与此同时Muirhead等人发现肾髓质可以产生两种具有降低血压作用的甘油酯,将其中一种命名为抗高血压极性肾髓质类酯(APRL)。1979年三个实验室分别探明PAF与APRL为同一类甘油磷脂。由于激活血小板仅是这类生物活性磷脂作用的一个方面,许多研究者认为PAF这一名称不能反应其本质而建议根据其化学结构重新命名之。因而文献中仍主要使用PAF这一名称的同时,也常见下列同义词:1-烷基-2-
Platelet-activating factor (PAF) was found in the early 70s. Benvenist et al. Found that basophils, after being stimulated by IgE, release a substance that causes platelet aggregation and degranulation, which is by far the strongest cause of platelet aggregation and named it PAF. In the meantime, Muirhead et al. Found that medulla can produce two blood-pressure-reducing glycerides, one of which is named antihypertensive polar medulla oblongata (APRL). In 1979, three laboratories respectively proved that PAF and APRL are the same type of glycerophospholipid. Since activating platelets is only one aspect of the role of such bioactive phospholipids, many researchers have suggested that the name PAF does not reflect its essence and is recommended to be renamed based on its chemical structure. Therefore, the main use of PAF in the literature is still the name, the following synonyms are common: 1-alkyl-2-