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通过伤口进入机体的~(239)Pu在适当剂量和一定时期内会引起大部分动物产生恶性肿瘤。长期应用Zn-DTPA和Ca-DTPA螯合剂治疗可以降低肿瘤、特别是骨肉瘤的发生率。本文旨在研究螯合剂在大量~(239)Pu侵入机体后的效果。实验采用234只Wistar大鼠,雄雌均用,体重170～180g,一次肌肉注入硝酸钚(iv,pH1.0),剂量为1.58MBq/kg,1小时后用Zn-DTPA和Ca-DTPA治疗,剂量为25mmol/kg,每天给药1次(1周用药5次),全疗程为64天。在不同时期于乙醚麻醉下杀死105只动物,取股骨进行放射性分析,钚从骨中排出的过程用数字表
The ~ (239) Pu entering the body through the wound causes most of the animals to develop malignancies at the appropriate dose and over a certain period of time. Long-term use of Zn-DTPA and Ca-DTPA chelator therapy can reduce the incidence of tumors, especially osteosarcoma. The purpose of this study was to investigate the effect of chelators on the intrusion of large amounts of 239 Pu. A total of 234 Wistar rats were used, both male and female, weighing 180-180 g and intramuscularly injected plutonium nitrate (iv, pH 1.0) at a dose of 1.58 MBq / kg. After 1 hour treatment with Zn-DTPA and Ca-DTPA , Dose of 25mmol / kg, administered once a day (1 week medication 5 times), the whole course of 64 days. 105 animals were killed at various times under ether anesthesia, femurs were taken for radiological analysis, and plutonium was removed from the bone using a digital watch