目的　探讨女工二硫化碳 (CS2 )接触水平与胚胎早期发育障碍之间的剂量—反应关系。方法　前瞻观察欲生育女工妊娠所需的月经周期数 ;收集每个月经周期胚胎植入期尿样 ,检测绒毛膜促性腺激素含量 ;监测女工作业地点CS2 浓度。结果　①接触组女工各月经周期妊娠机率低于对照组 ,时间妊娠率随接触水平 (孕时CS2 接触浓度乘以CS2 接触工龄 )升高而降低 :妊娠率 =0 70 3 3 -0 0 0 15×接触水平 ( χ2 =64 71,P =0 .0 0 0 ;r =-0 .979,P =0 .0 0 0 ) ;②检测 3 4 0个月经周期尿样的早早孕丢失率 ,接触组明显高于对照组 ,且随接触水平升高而增加 :丢失率 =0 4717+0 0 0 2 8×接触水平 ( χ2 =2 5 .5 9,P =0 .0 0 1,r =0 .977,P =0 0 0 0 )。结论　随着接触水平的增高 ,早早孕丢失率明显增加 ;每个月经周期妊娠率降低 ,均呈现出明显的剂量—反应关系 ,表明CS2 对胚胎早期发育的损伤作用具有蓄积性 Objective To investigate the dose-response relationship between female CS2 exposure and early embryonic developmental dysfunction. Methods Prospective observation of the number of menstrual cycles required for pregnant women pregnant; collected during each menstrual cycle of embryonic urine samples were collected to detect the concentration of human chorionic gonadotropin; CS2 workplace women monitoring the concentration. Results ①The pregnancy rate of female workers in contact group was lower than that of control group in menstrual cycle, and the time pregnancy rate decreased with the increase of exposure level (CS2 contact concentration multiplied by CS2 exposure during pregnancy): pregnancy rate = 0 70 3 3 -0 0 0 15 × contact level (χ2 = 6471, P = 0.0000; r = -0.979, P = 0.0000); ②The early pregnancy loss rate of 340 urine samples during the menstrual cycle Group was significantly higher than the control group, and increased with the increase of exposure level: loss rate = 0 4717 + 0 0 0 2 8 × exposure level (χ2 = 25.55, P = 0.010, r = 0 .977, P = 0 0 0 0). Conclusions With the increase of exposure level, the rate of early pregnancy loss increased obviously. The pregnancy rate decreased in each menstrual cycle, showing obvious dose-response relationship, indicating that CS2 has an accumulative effect on the early embryonic development injury