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目的：研究丝瓜叶新成分Ｌ６ａ和Ｌ１０对大鼠学习记忆及海马内生长抑素的影响．方法：ｉｃｖ大鼠分别用穿梭箱被动回避反应及免疫组化、图像分析等法进行．结果：Ｌ６ａ（２５μｇ）组记忆保持功能明显增强（Ｐ＜００５），生长抑素免疫反应物（ＳｏｍＬＩ）的面密度和数密度显著增加（Ｐ＜００５）；其余各组记忆保持功能增加不显著（Ｐ＞００５），Ｌ１０（２５μｇ）组ＳｏｍＬＩ的面密度及（５０μｇ）组ＳｏｍＬＩ的面密度和数密度值均显著增加（Ｐ＜００５）．结论：Ｌ６ａ（２５μｇ）具有增强记忆保持功能和增加ＳｏｍＬＩ的作用，Ｌ１０有增强记忆保持功能的趋势，但不显著，却显著增加海马内的ＳｏｍＬＩ．
Objective: To study the effects of new components L 6 6a and L 10 of Loofah on learning and memory and somatostatin in hippocampus of rats. Methods: icv rats were treated with shuttle box passive avoidance, immunohistochemistry and image analysis. RESULTS: The memory retention function of L 6a (25μg) group was significantly increased (P 0. 05), and the areal density and number density of som LI were significantly increased (P 0. 05); There was no significant increase in memory retention in each group (P>005). The surface density of Som-LI in L-10 (25μg) group and the surface density and number density of Som-LI (50μg) increased significantly (P< 005). Conclusion: L 6a (25μg) has the function of enhancing memory retention and increasing Som LI. L 10 has the tendency to enhance the memory retention, but it is not significant, but it significantly increases Som LI in the hippocampus.