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目的探讨肝脏疾病患者血清视黄醇结合蛋白(RBP)、总胆红素(TBIL)、总胆汁酸(TBA)、丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、前白蛋白(PA)的表达水平及检测的临床意义。方法检测33例肝损害患者、17例肝硬化患者、21例急性肝炎患者、26例慢性肝炎患者和50例对照者的血清RBP、TBIL、TBA、ALT、AST和PA水平。结果各疾病组血清RBP、TBIL、TBA、ALT、AST和PA水平与对照组比较差异有统计学意义(P<0.01);肝损害组RBP、ALT和PA显著高于肝硬化组;肝硬化组ALT低于急性肝炎组,TBIL和TBA显著高于慢性肝炎组;急性肝炎组TBIL和TBA水平高于慢性肝炎组,上述差异均有统计学意义(P<0.05)。RBP和PA在各疾病组均有较高阳性检出率。ALT和AST在肝损害组阳性检出率最高。结论血清RBP、TBIL、TBA、ALT、AST和PA水平的检测能很好的反应肝脏损害情况,为肝病的鉴别诊断、临床治疗监测提供有力依据。
Objective To investigate the expression of serum retinol binding protein (RBP), total bilirubin (TBIL), total bile acid (TBA), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) , Prealbumin (PA) expression levels and detection of clinical significance. Methods Serum levels of RBP, TBIL, TBA, ALT, AST and PA were measured in 33 patients with liver damage, 17 patients with cirrhosis, 21 patients with acute hepatitis, 26 patients with chronic hepatitis and 50 controls. Results The serum levels of RBP, TBIL, TBA, ALT, AST and PA in all disease groups were significantly different from those in control group (P <0.01). RBP, ALT and PA in liver damage group were significantly higher than those in liver cirrhosis group The levels of ALT in acute hepatitis group, TBIL and TBA group were significantly higher than those in chronic hepatitis group. The levels of TBIL and TBA in acute hepatitis group were higher than those in chronic hepatitis group. The differences were statistically significant (P <0.05). RBP and PA in each disease group have a higher positive detection rate. ALT and AST in liver damage group positive detection rate. Conclusion The detection of serum RBP, TBIL, TBA, ALT, AST and PA levels can well reflect the liver damage and provide a strong evidence for the differential diagnosis and clinical treatment of liver disease.