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利用血管内高频超声（Ｉｎｔｒａｖａｓｃｕｌａｒ Ｕｌｔｒａｓｏｕｎｄ，ＩＶＵＳ）成像技术，对ＩＶＵＳ图像灰度值进行换能器偏心校正后，提出基于遗传算法的管壁组织运动分阶叠加光流估计方法获得血管内施压条件下组织微元位移与应变分布，采用弹性重构方法在世界上首次获得了实际血管壁真正意义上的横断面弹性显微图像。由离体猪血管实验结果证实．将血管力学实验研究推进到二维亚毫米微结构层次，有希望为经皮腔内冠状动脉血管成形术（Ｐｅｒｃｕｔａｎｅｏｕｓ Ｔｒａｎｓｌｕｍｉｎａｌ Ｃｏｒｏｎａｒｙ Ａｎｇｉｏｐｌａｓｔｙ， ＰＴＣＡ）过程监控与治疗评价提供新的技术手段。
Intravascular Ultrasound (IVUS) imaging was used to calibrate the IVUS image gray value by using the transducer eccentricity correction. Then, a genetic algorithm was proposed to estimate the intraluminal tissue movement gradient and optical flow estimation Under the conditions of the organization of micro-displacement and strain distribution, the use of elastic reconstruction method for the first time in the world real vascular wall real cross-sectional elastic microscopic images. Porcine vasculature from the experimental results confirmed. Promote the experimental research of vascular mechanics to two-dimensional sub-millimeter microstructure level, and hopefully provide a new technical means for the monitoring and treatment evaluation of percutaneous transluminal coronary angioplasty (PTCA).