In the complex mechanical vibration environment, the dominant frequency of the system varies remarkably and swiftly under various running conditions, which also characterizes uncertainty and time-variation. It is very impending and important to suppress or isolate the detrimental vibrations related to the above memtoned system with active vibration control (AVC) technology. This paper presented the improved linear quadratic gaussian (LQG) control scheme with a specified filter to realize broadband disturbance/noise attenuation and assure intensive suppression of vibration at the key vibration frequency, then applies and modifies the multiple model switching tuning (MMST) control method by disturbance observation to track the variation of dominant vibration component timely. The effectiveness and superiority of the presented control method were demonstrated by numerical simulation and AVC experiment on a flexible cantilever beam under sweeping excitation.