MicroRNA pathway is down-regulated in aged dopaminergic neurons:Parkinson’s disease(PD)is the most frequent motor neurodegenerative disorder and is morphologically mainly associated with progressive dopaminergic neuronal loss in the ventral midbrain.The cause of this pathology is unknown,but aging is well established as the strongest risk factor,which by far prevails over gender, MicroRNA pathway is down-regulated in age dopaminergic neurons: Parkinson’s disease (PD) is the most frequent motor neurodegenerative disorder and is morphologically mainly associated with progressive dopaminergic neuronal loss in the ventral midbrain. The cause of this pathology is unknown, but aging is well established as the strongest risk factor, which by far prevails over gender,