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脑缺血再灌注损伤是一个动态的病理过程，它导致脑卒中患者的病情加重甚至致残。这几年，人们致力于研究各种炎性因子与脑缺血再灌注损伤的关系，虽然取得一些成果但具体机制尚未明确。白介素-1β( IL-1β)作为炎性反应的起始因子和最重要的因素参与体内免疫反应的调节及产生级联炎症反应参与脑缺血再灌注后的神经损伤，成为研究的热点，文就IL-1β与脑缺血再灌注损伤研究的最新进展做一综述。“,”Cerebral ischemia reperfusion injury is a dynamic process of pathology which leads to illness or disability in the pa-tients with cerebral apoplexy. In recent years the relationship between inflammatory factors and cerebral ischemia reperfusion injury but the specific mechanism is unclear yet. Interleukin 1 beta ( IL - 1 beta) as the most important factor in the initial factor of inflammato-ry reaction participates in the regulation of immune response in the body and produces inflammation cascade reaction involved in neuro-logical damage after cerebral ischemia reperfusion and becomes a research hotspot. This paper reviews the latest progress research in interleukin-1 beta ( IL-1 beta) and the cerebral ischemia reperfusion injury.