目的:研究筋骨痛消丸的急性毒性及长期毒性。方法:小鼠急性毒性试验采用最大耐受量法;长期毒性试验以大鼠80只,随机分成4组,采用3个剂量组,每天灌胃给药1次,连续给药3个月,处死一半动物,其余动物停药进行恢复期观察2周,观察大鼠的生长发育、活动、体重等情况,并进行血液学、生化学、病理学等检查。结果:急性毒性实验未见明显毒性反应,小鼠对筋骨痛消丸的最大耐受量为72 g/kg,为临床用药量的360倍;长期毒性实验结果显示,高、中、低剂量组动物未出现中毒表现,各脏器无病理性变化。结论:筋骨痛消丸在规定剂量下服用是安全可靠的。 Objective: To study the acute toxicity and long-term toxicity of Bugundongxiao pills. Methods: Acute toxicity test in mice was performed with maximum tolerated dose. Eighty rats were randomly divided into four groups. Three dose groups were given intragastrically once a day for 3 months and were sacrificed Half of the animals, the rest of the animals were withdrawn for recovery for 2 weeks to observe the growth and development of rats, activity, weight and other conditions, and hematology, biochemistry, pathology and other tests. Results: The acute toxicity test showed no obvious toxic reaction. The maximum tolerated dose of Bugu Tongxiao Pill was 72 g / kg, which was 360 times of the clinical dose. The long-term toxicity test showed that the high, medium and low dose groups The animals did not appear poisoning performance, no pathological changes of various organs. Conclusion: Gutongtongxiao Wan is safe and reliable under the prescribed dosage.