1临床资料患者男,39岁。双足多发性溃疡伴疼痛1年。患者于5年前诊断为慢性粒细胞白血病,每天予口服羟基脲1.0g～3.0g持续至今。1年前,患者双足先后出现粟粒大红色丘疹,伴疼痛,皮损逐渐增大,呈暗红色结节,顶端有脓疱,破溃后表面形成溃疡。溃疡逐渐变大并变深。当地医院予自制药物外搽,无好转,患足疼痛剧烈,以夜间为甚,并伴有肢体活动受限。否认下肢静脉曲张及糖尿病病史和肿瘤家族史。家族中无类似疾病患者。体检:T36.4℃,一般情况可,浅表淋巴结无肿大,系统查体未发现异常。皮肤科情况:双手散在分布大小不等及不规则 1 clinical data patient male, 39 years old. Two feet of multiple ulcers with pain for 1 year. 5 years ago, patients diagnosed as chronic myeloid leukemia, oral administration of hydroxyurea 1.0g ~ 3.0g daily so far. A year ago, the patients had large miliary papules, accompanied by pain, skin lesions gradually increased, dark red nodules, the top of the pustules, rupture ulceration on the surface. Ulcers become larger and darker. The local hospital to homemade drugs Waicha, no improvement, severe painful foot pain, even at night, and accompanied by physical activity is limited. Denied varicose veins and diabetes history and family history of cancer. No similar disease in the family. Physical examination: T36.4 ℃, the general situation can be, superficial lymph nodes without swelling, the system examination found no abnormalities. Dermatology: hands scattered distribution of sizes and irregular