目的 :研究Nd :YAP激光不同功率、照射时间对胃的生物效应的影响。方法 :以犬作为实验对象 ,以不同功率、不同照射时间照射胃 ,以肉眼、光镜、电镜观察不同激光参数的生物学作用。结果 :Nd :YAP激光作用于胃 ,以热凝固效应为主 ,并有一定的消融作用。病理见全层凝固变性剂量 10W、5秒 ,2 0W、4秒 ,30W、2秒 ,4 0W～ 6 0W、1秒 ;结论 :Nd :YAP激光作用于胃组织 ,以 10W、5秒 ,2 0W、4秒 ,30W、2秒以下的剂量较安全 ,可减少穿孔的机率。Nd :YAP激光的组织表面消融、热凝固作用与平均功率、照射时间成正相关 Objective: To study the effect of different power and irradiation time of Nd: YAP laser on the biological effect of stomach. Methods: The dogs were used as experimental subjects, the stomach was irradiated with different power and different irradiation time, and the biological effects of different laser parameters were observed by naked eye, light microscope and electron microscope. Results: The Nd: YAP laser was applied to the stomach with the main effect of thermal coagulation and ablation. Pathological see full-thickness coagulation denaturation dose 10W, 5 seconds, 20W, 4 seconds, 30W, 2 seconds, 40W ~ 60W, 1 second; Conclusion: Nd: YAP laser in gastric tissue to 10W, 5 seconds, 2 0W, 4 seconds, 30W, 2 seconds the following dose is safer, can reduce the probability of perforation. Nd: YAP laser tissue surface ablation, thermal coagulation and the average power, irradiation time is positively correlated