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糖尿病肾病 (DN)患者肾脏局部纤溶酶原激活物抑制物 1(PAI 1)表达增加 ,抑制了肾小球及肾小管间质细胞外基质 (ECM)的降解 ,导致ECM进行性堆积 ,肾小球基底膜增厚 ,肾小球硬化。DN时血管紧张素Ⅱ在转录水平上可上调PAI 1基因表达 ,高糖增加PAI 1的含量和活性 ,且转化生长因子 β能诱导PAI 1的产生 ,从而导致肾小球硬化的发生。PAI 1抑制剂的应用将对防治DN起一定的作用
Increased expression of renal plasminogen activator inhibitor 1 (PAI 1) in diabetic nephropathy (DN) inhibits the degradation of glomerular and tubular interstitial extracellular matrix (ECM) resulting in the progressive accumulation of ECM, Pelvic basement membrane thickening, glomerular sclerosis. At angiotensin Ⅱ, angiotensin Ⅱ can up-regulate the expression of PAI 1 gene at transcriptional level, and increase the content and activity of PAI 1 by high glucose, and TGF-β can induce the production of PAI 1, leading to the occurrence of glomerulosclerosis. The use of PAI 1 inhibitors will play a role in the prevention and treatment of DN