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目的:研究KLK7蛋白在卵巢上皮性肿瘤组织中的表达及与肿瘤的临床病理特征的相关性。方法:采用免疫组织化学方法检测50份卵巢上皮性癌,20份卵巢交界性肿瘤,10份卵巢良性肿瘤,10份正常卵巢组织中KLK7蛋白的表达,并分析其临床意义。结果:KLK7蛋白在卵巢癌组织中的阳性表达率(68.0%)明显高于交界性肿瘤,良性肿瘤及正常卵巢组织(分别为30.0%,20.0%,10.0%,P<0.05),在卵巢癌组织中,KLK7蛋白阳性表达率与手术病理分期,病理分级,淋巴结转移有关(P<0.05)。结论:KLK7基因可能通过KLK7蛋白促进肿瘤的生长,浸润与转移,临床可以通过检测KLK7蛋白的表达率推断肿瘤的预后,选择治疗方案。
Objective: To study the expression of KLK7 protein in ovarian epithelial tumor and its correlation with clinicopathological features. Methods: Immunohistochemistry was used to detect the expression of KLK7 in 50 ovarian epithelial carcinomas, 20 ovarian borderline tumors, 10 benign ovarian tumors and 10 normal ovarian tissues. The clinical significance was analyzed. Results: The positive rate of KLK7 protein expression in ovarian cancer tissues was significantly higher than that in borderline tumors, benign tumors and normal ovarian tissues (30.0%, 20.0%, 10.0%, P <0.05, respectively) The positive expression rate of KLK7 protein in the tissue correlated with the pathological stage, pathological grade and lymph node metastasis (P <0.05). Conclusion: The KLK7 gene may promote the growth, invasion and metastasis of tumor by KLK7 protein. Clinically, the prognosis of the tumor can be deduced by detecting the expression of KLK7 protein and the treatment regimen can be selected.