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目的研究新疆部分地区汉族、维吾尔族帕金森病(Parkinson disease,PD)患者认知障碍和神经精神状况特点。方法收集2008-2013年在新疆部分三级甲等医院就诊并经确诊的PD患者216例,采用简易智能状态检查量表(MMSE)评定患者认知功能,采用神经精神问卷评定患者的神经精神状况。结果汉族PD患者有神经精神症状(neuropsychiatric symptoms,NPS)者占82.14%(115/140),维吾尔族PD患者有NPS者占57.89%(44/76),两组间比较差异有统计学意义(P<0.01);两民族PD患者抑郁、焦虑、过度兴奋、易怒症状、睡眠/睡眠夜间行为发生率存在统计学差异(均P<0.05)。伴认知功能障碍的汉族和维吾尔族PD患者NPS发生率间比较差异无统计学意义(78.94%比84.61%;χ2=0.326,P=0.568)。汉族PD患者中,伴认知功能障碍者与非伴认知功能障碍者间NPS异常发生率比较差异无统计学意义〔78.94%比75.49%;χ2=0.184,P>0.05〕,而维吾尔族患者中伴认知功能障碍与非伴认知功能障碍者间其异常率比较差异有统计学意义〔86.41%比56.00%;χ2=6.223,P<0.05〕。结论汉族PD患者NPS发生率高于维吾尔族PD患者,伴有认知障碍的维吾尔族PD患者NPS发生率较非伴认知功能障碍者高,推测民族及宗教可能是影响因素之一。
Objective To investigate the characteristics of cognitive disorders and neuropsychiatric disorders in Han and Uygur nationalities in parts of Xinjiang. Methods Totally 216 patients with PD diagnosed and diagnosed in some Grade-3 Hospitals in Xinjiang from 2008 to 2013 were collected. MMSE was used to assess the patients’ cognitive function. The neuropsychiatric questionnaire was used to assess the neuropsychiatric status . Results Han patients with neuropsychiatric symptoms accounted for 82.14% (115/140) in PD patients and 57.89% (44/76) in Uygur PD patients with NPS, the difference was statistically significant (P < P <0.01). There was a significant difference in the incidence of depression, anxiety, over-excitement, irritability and nighttime sleep / sleep between two ethnic PD patients (all P <0.05). There was no significant difference in the incidence of NPS between Han and Uygur PD patients with cognitive impairment (78.94% vs 84.61%; χ2 = 0.326, P = 0.568). Han patients with PD, with cognitive impairment and non-cognition dysfunction, the incidence of NPS abnormalities was no significant difference (78.94% vs 75.49%; χ2 = 0.184, P> 0.05), while Uighur patients There was significant difference in the abnormal rate between middle-class cognitive impairment and non-cognitive impairment (86.41% vs 56.00%; χ2 = 6.223, P <0.05). Conclusions The incidence of NPS in Han patients with PD is higher than that in Uyghur PD patients. The incidence of NPS in Uygur PD patients with cognitive impairment is higher than that in non-cognized PD patients, suggesting that ethnicity and religion may be one of the influencing factors.