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探讨骨骼肌废用性萎缩、恢复中内源性IGF-I的影响,及小强度耐力锻炼对肌萎缩恢复的有效性。SD大鼠30只,建立吊尾拟失重及失重后耐力性跑台训练恢复模型,计量肌湿重、横截面积及肌内IGF-I含量。结果去负荷4周(U组)肌湿重、横截面积高度显著低于对照组(C组),去负荷后运动恢复(UE组)与自然恢复(UC组)相应指标显著高于U组;U组IGF-I含量显著低于C组,和U组相比,IGF-IUE组高度显著增加、UC组显著增加;UE、UC组间三项指标变化均无显著差异。结论去负荷大鼠比目鱼肌萎缩可能与内源性IGF-I多肽下降有关,且随后小强度耐力练习使比目鱼肌恢复更快可能由IGF-I多肽表达增加实现;小强度耐力性练习在肌萎缩恢复中未见显著作用,提示实践中这可能不是抗肌萎缩的最合适练习方法。
To investigate the effect of endogenous IGF-I on the atrophy and recovery of skeletal muscle, and the effect of low-intensity endurance training on the recovery of amyotrophy. Thirty SD rats were established, and the recovery model of the endurance-losing treadmill training was set up to measure the muscle wet weight, cross-sectional area and intramuscular IGF-I content. Results Compared with control group (C), the wet weight and cross-sectional area of group U at the end of 4 weeks of loading (U group) were significantly higher than that of U group (UE group) and spontaneous recovery group (UC group) ; The IGF-I content in U group was significantly lower than that in C group. Compared with U group, the IGF-IUE group increased significantly and the UC group increased significantly. There was no significant difference between the three groups in UE and UC groups. CONCLUSION: Intestinal atrophy may be related to the decrease of endogenous IGF-I polypeptide in the unloaded rats, and then the recovery of soleus muscle may be realized by the increased expression of IGF-I polypeptide after low-intensity endurance exercise. The exercise of low-intensity endurance in amyotrophy There was no significant effect in recovery, suggesting that in practice this may not be the most appropriate exercise for resistance to muscle atrophy.