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为探讨一氧化氮（ＮＯ）在Ⅱ型糖尿病（ＮＩＤＤＭ）初发者、早期糖尿病肾病及糖尿病神经性病变患者中的变化，对７８例ＮＩＤＤＭ患者进行血清ＮＯ稳定代谢产物亚硝酸盐和硝酸盐（ＮＯ２－ＮＯ３）检测分析，并与３０例正常人比较。结果，ＮＩＤＤＭ初发者及早期糖尿病肾病患者血清ＮＯ水平均显著高于正常人（Ｐ＜０．０５～０．０１）；糖尿病神经性病变患者血清ＮＯ显著低于正常人（Ｐ＜０．０１）。提示ＮＩＤＤＭ的发生及并发症均有ＮＯ的参与。
To investigate the changes of nitric oxide (NO) in patients with type 2 diabetes (NIDDM), early diabetic nephropathy and diabetic neuropathy, 78 patients with NIDDM were enrolled in this study. Serum nitric oxide and nitric oxide NO2-NO3) test analysis, and compared with 30 normal subjects. Results Serum NO levels in patients with NIDDM and early diabetic nephropathy were significantly higher than those in normal controls (P <0.05-0.01). Serum NO levels in patients with diabetic neuropathy were significantly lower than those in normal controls (P <0.01) ). Prompt NIDDM occurrence and complications are involved in NO.