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目的:分析0～6月龄婴儿川崎病(KD)的临床特点。方法:收集2001年1月～2011年12月≤6月龄KD患儿55例,≤6月龄组又分为冠状动脉病变组(CAL)和冠状动脉正常组(NCAL),并于同期收治的>6月龄KD患儿452例进行比较。结果:球结膜充血率、口唇改变率、颈部淋巴结肿大率、不完全KD率、冠脉改变率,≤6月龄组明显低于>6月龄组(P<0.05)。≤6月龄组川崎病患儿临床症状不典型,球结膜充血,颈部淋巴结及口唇改变少见,确诊时间长,不完全KD的发病率及冠脉损害率明显升高;C反应蛋白、血沉、清蛋白、发热时间、白细胞计数、血小板计数、≤6月龄的CAL组与NCAL相比均无统计学差异(P>0.05)。CAL组的粒细胞数胆显高于NCAL组(P<0.05)。结论:6个月内小婴儿由于临床症状不典型,不完全KD及冠脉损害率升高明显,诊断困难,其冠脉的发生率与粒细胞升高有关。
Objective: To analyze the clinical features of KD in children aged 0-6 months. Methods: From January 2001 to December 2011, 55 children with KD ≤ 6 months old and ≤ 6 months old were divided into two groups: coronary artery disease group (CAL) and normal coronary artery group (NCAL), and were treated at the same period 452 KD children> 6 months of age were compared. Results: The conjunctival hyperemia rate, lip change rate, cervical lymph node enlargement rate, incomplete KD rate and coronary artery change rate were significantly lower than 6 months old group (P <0.05). ≤ 6 months old Kawasaki disease in children with atypical clinical symptoms, conjunctival hyperemia, cervical lymph nodes and lip changes rare, long diagnosis, incomplete KD incidence and coronary artery injury rate was significantly increased; C-reactive protein, erythrocyte sedimentation rate , Albumin, fever time, white blood cell count, platelet count, ≤ 6 months of CAL group and NCAL no significant difference (P> 0.05). The number of granulocytes in CAL group was significantly higher than that in NCAL group (P <0.05). CONCLUSIONS: Small infants within 6 months are not typical due to clinical symptoms, incomplete KD and coronary artery injury rate increased significantly, diagnosis is difficult, the incidence of coronary artery and granulocyte rise.