1例16岁女性患者因精神分裂症口服富马酸喹硫平,起始剂量100 mg,晚间1次,逐渐加量,至用药第40天增至600 mg/d(200 mg日间1次4,00 mg晚间1次)。当天患者出现不自主摇头和眨眼症状。其症状考虑与富马酸喹硫平相关,为此将其剂量减至400 mg,晚间1次。第3天患者发展为急性肌张力障碍。立即停用富马酸喹硫平,改为口服奥氮平,同时肌内注射丁溴东莨菪碱0.3 mg,静脉滴注5%葡萄糖注射液500 ml及葡萄糖氯化钠注射液1000 ml。第2天患者肌张力障碍症状消失。 A 16-year-old female patient received oral quetiapine fumarate because of schizophrenia. The initial dose of 100 mg was given at night and then gradually increased to 600 mg / d (200 mg once daily during the first 40 days) 4,00 mg once night). The patient showed involuntary shaking his head and blinking symptoms on that day. Its symptoms are related to quetiapine fumarate, for which dose is reduced to 400 mg once night. On the third day the patient developed acute dystonia. Immediate withdrawal of quetiapine fumarate, to oral olanzapine, intramuscular injection of scopolamine butane 0.3 mg, intravenous infusion of 5% glucose injection 500 ml and glucose sodium chloride injection 1000 ml. On the second day, the symptoms of dystonia disappeared.