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目的:探讨沙格列汀对糖尿病肾病患者肾功能的影响。方法:选取2014年10月至2015年10月于湛江中心人民医院就诊的2型糖尿病血糖控制不佳患者120例,根据尿微量白蛋白(UAE)分为3组:A组无蛋白尿组46例、B组微量蛋白尿组42例、C组大量蛋白尿组32例,每组随机分成治疗组与观察组,治疗组予以胰岛素+沙格列汀治疗,对照组单纯予以胰岛素治疗。测量患者UAE、肌酐(Cr)、胱抑素C(CysC)等指标,比较观察组、对照组治疗前后各观察指标的差异。结果:A组(无蛋白尿组)中,观察组与对照组治疗前后各项指标无明显差异;B组(微量蛋白尿组)和C组(大量蛋白尿组)中,加用沙格列汀后,肾功能相关的各项指标均好转,差异具有统计学意义(P<0.05);观察组治疗前后各指标相比,差异均无统计学意义(P>0.05);和观察组治疗后比较,差异有统计学意义(P<0.05)。结论:沙格列汀对糖尿病肾病患者肾功能有一定的帮助,对于糖尿病伴有糖尿病肾病患者的治疗安全有效。
Objective: To investigate the effect of saxagliptin on renal function in patients with diabetic nephropathy. Methods: A total of 120 patients with type 2 diabetes mellitus with poor glycemic control who were treated in Zhanjiang Central People’s Hospital from October 2014 to October 2015 were enrolled in this study. Patients were divided into three groups according to urinary albuminuria (UAE) For example, 42 cases of microalbuminuria in group B and 32 cases of massive proteinuria in group C were randomly divided into treatment group and observation group. Patients in treatment group were treated with insulin and saxagliptin, while those in control group were treated with insulin alone. Measurement of UAE, creatinine (Cr), Cystatin C (CysC) and other indicators were compared between the observation group and the control group before and after treatment of the observed indicators of the difference. Results: There was no significant difference between the observation group and the control group before and after treatment in group A (proteinuria-free group); in group B (microalbuminuria group) and group C (mass proteinuria group) (P <0.05). There was no significant difference in each index between before and after treatment in the observation group (P> 0.05); after the treatment, the indexes of renal function were all improved The difference was statistically significant (P <0.05). Conclusion: Saxagliptin is helpful to the renal function of patients with diabetic nephropathy, which is safe and effective for the treatment of diabetic patients with diabetic nephropathy.