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目的观察复方丹参注射液联合硫酸镁对轻度子痫患者肾功能的影响。方法将212例轻度子痫前期患者随机分为研究组和对照组各106例。对照组采用硫酸镁进行治疗,研究组采用复方丹参注射液联合硫酸镁治疗,治疗后对比2组临床疗效和肾功能指标变化情况。结果研究组总有效率为98.11%高于对照组的78.30%,差异均有统计学意义(P<0.05)。治疗前2组血肌酐、血尿酸、血尿素氮、尿蛋白、平均动脉压水平差异无统计学意义(P>0.05)。治疗后2组上述指标均低于治疗前,且研究组低于对照组,差异均有统计学意义(P<0.05)。结论复方丹参注射液联合硫酸镁治疗轻度子痫前期的效果优于单一硫酸镁治疗,值得临床推广应用。
Objective To observe the effects of compound Danshen injection combined with magnesium sulfate on renal function in patients with mild eclampsia. Methods 212 mild preeclampsia patients were randomly divided into study group and control group, 106 cases each. The control group was treated with magnesium sulfate. The study group was treated with Compound Danshen Injection and Magnesium Sulfate. After treatment, the changes of clinical efficacy and renal function were compared between the two groups. Results The total effective rate of the study group was 98.11%, which was significantly higher than that of the control group (78.30%) (P <0.05). Serum creatinine, blood uric acid, blood urea nitrogen, urine protein and mean arterial pressure had no significant difference between the two groups before treatment (P> 0.05). After treatment, the above indexes of two groups were lower than before treatment, and the study group was lower than the control group, the difference was statistically significant (P <0.05). Conclusion Compound Danshen injection combined with magnesium sulfate in the treatment of mild preeclampsia is superior to single magnesium sulfate treatment, which is worthy of clinical application.