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目的研究精素静脉曲张手术治疗对血清抑制素B(inhibinB,简称InhB)水平的影响,从而了解精素静脉曲张不育患者手术后生育能力的变化。方法选取30例患有精素静脉曲张的男性不育患者,对所有患者行腹膜后精索内静脉高位结扎术,分别于手术前和手术后3个月测定血清InhB、卵泡刺激素(FSH)、黄体生成素(LH)、睾酮(T)和精子密度,分析它们的变化。结果精索静脉曲张不育患者手术后较手术前血清InhB水平显著升高;血清FSH、LH、T手术前后均无显著性变化;精子密度手术后较手术前显著提高。结论精素静脉曲张手术治疗能使血清InhB水平升高,从而说明了手术对精子发生及支持细胞功能的改善。
Objective To study the effect of varicose veins surgery on the level of inhibin B (InhB) in order to understand the changes of fertility after varicocele inpatients. Methods Thirty male infertile patients with varicocele were enrolled in this study. All patients underwent retroperitoneal spermatic vein ligation. Serum InhB, follicle-stimulating hormone (FSH) were measured before and 3 months after operation. , Luteinizing hormone (LH), testosterone (T) and sperm density, and analyze their changes. Results The infertile patients with varicocele had a significantly higher InhB level than those before operation. There was no significant difference in serum FSH, LH and T before and after operation. The sperm density was significantly higher than that before operation. Conclusion Surgical treatment of varicocele can increase the level of serum InhB, which indicates the improvement of spermatogenesis and supporting cell function by surgery.