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目的观察急性有机磷农药中毒(AOPP)的心肌酶谱改变及纳洛酮的疗效。方法将110例AOPP患者随机分为纳洛酮治疗组(56例)和常规治疗组(54例)。两组患者均于入院后24h内采取血样,检测心肌酶谱水平。两组病例首先按AOPP的内科综合治疗方法进行急救,治疗组加用纳洛酮,首剂0.4～1.2mg静脉注射,维持量0.01mg/min。结果①Aopp患者血清心肌酶谱活性均有不同程度升高,且中毒程度越重,心肌酶谱升高越明显。②两组患者在死亡率、阿托品中毒、反跳、中间综合征、昏迷时间及平均住院天数的比较差异有统计学意义(P<0.05)。结论①心肌酶谱活性的检测,对Aopp患者病情估计具有一定的临床价值。②纳洛酮对急性有机磷农药中毒有良好的临床治疗效果,应推广使用。
Objective To observe the changes of myocardial enzymes and the efficacy of naloxone in acute organophosphorus pesticide poisoning (AOPP). Methods 110 patients with AOPP were randomly divided into naloxone treatment group (56 cases) and conventional treatment group (54 cases). Two groups of patients were taken within 24h after admission, blood samples were taken to detect myocardial enzymes. First two groups of patients according to AOPP comprehensive medical treatment for first aid, the treatment group plus naloxone, the first dose of 0.4 ~ 1.2mg intravenously, maintenance dose 0.01mg / min. Results ①Aopp patients serum myocardial enzyme activity increased to varying degrees, and the more severe poisoning, the more obvious myocardial enzyme increased. ② There was significant difference between the two groups in mortality, atropine poisoning, rebound, intermediate syndrome, coma time and average hospitalization days (P <0.05). Conclusions ① The detection of myocardial enzyme activity has certain clinical value in estimating the disease in Aopp patients. ② naloxone on acute organophosphorus pesticide poisoning has a good clinical effect, should be widely used.