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目的 探讨细胞周期蛋白D1(cyclin D1)基因的表达与肺癌的临床分期及肿块大小的相关性。方法 利用免疫组化技术(SP法),检测了cyclin D1基因在108例不同临床分期及不同肿块大小的肺癌石蜡包埋组织中的表达,其结果采用定性的方法进行分析,,结果 cyclin D1的表达与肺癌肿块大小呈正相关;而与肺癌的临床分期无相关性。结论 cyclin D1蛋白是一种原癌基因,cyclin D1基因只在肿瘤组织中呈过表达状态,cyclin D1基因的过表达在肺癌尤其是非小细胞肺癌的发生、发展中起重要作用。
Objective To investigate the relationship between the expression of cyclin D1 (cyclin D1) gene and the clinical stage and tumor size of lung cancer. Methods Immunohistochemical technique (SP method) was used to detect the expression of cyclin D1 gene in paraffin-embedded tissues of 108 lung cancer cases with different clinical staging and different tumor sizes. The results were analyzed by qualitative methods. Results of cyclin D1 The expression was positively correlated with the size of the lung mass, but not with the clinical stage of lung cancer. Conclusion The cyclin D1 protein is a proto-oncogene. The cyclin D1 gene is only overexpressed in tumor tissues. The overexpression of cyclin D1 plays an important role in the occurrence and development of lung cancer, especially non-small cell lung cancer.