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目的评价采用心肌标记技术的低剂量多巴酚丁胺负荷MR用于检测缺血心肌室壁运动异常的价值。方法8只犬通过结扎左冠状动脉前降支第一对角支远侧建立急性心肌梗死模型后,行低剂量多巴酚丁胺负荷下的电影MR(c ine-MR)和采用心肌标记技术的低剂量多巴酚丁胺负荷下的c ine-MR,分析和对比左心室壁运动。结果c ine-MR扫描负荷前后的左心室各节段室壁运动得分指数(wallmotion score index,WMSI)有显著差异(1.44±0.16 vs 1.32±0.16,P=0.002),采用标记技术扫描负荷前后也有显著差异(1.48±0.12 vs 1.21±0.10,P=0.001)。而且,2种不同方法检测的负荷下的WMSI也有明显差异(1.32±0.16 vs 1.21±0.10,P=0.049)。结论采用心肌标记技术的低剂量多巴酚丁胺负荷下的c ine-MR比未采用心肌标记技术检测出更多的室壁运动异常,它是一种客观准确评价室壁运动异常的工具。
Objective To evaluate the value of low-dose dobutamine stress MR with myocardial markers for the detection of abnormal myocardial wall motion in ischemic myocardium. Methods Eight dogs underwent acute myocardial infarction (AMI) by ligating the distal side of the first diagonal branch of left anterior descending coronary artery (LADC), and then underwent cine MR (cine-MR) under low-dose dobutamine stress. C ine-MR under low-dose dobutamine stress, analyzed and compared left ventricular wall motion. Results The wall motion score index (WMSI) of each segment of left ventricular before and after c ine-MR scanning was significantly different (1.44 ± 0.16 vs 1.32 ± 0.16, P = 0.002). Before and after the scanning with load, Significant difference (1.48 ± 0.12 vs 1.21 ± 0.10, P = 0.001). Moreover, there were also significant differences in WMSI under the two different assays (1.32 ± 0.16 vs 1.21 ± 0.10, P = 0.049). Conclusions The c ine-MR of low-dose dobutamine stress-loaded myocardial perfusion method is more effective than non-myocardial perfusion technique in detecting myocardial abnormalities. It is an objective and accurate tool to evaluate abnormalities of wall motion.