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目的分析北京市先天性甲状腺功能低下症(congenital hypothyroidism,CH)发病率变化和发病趋势,为合理制定CH的防治、保健的策略及措施提供科学依据。方法利用北京市开展新生儿疾病筛查的1994-2011年资料,进行描述性分析及统计推断。结果 18年来,北京市CH的发病率呈逐年上升趋势,平均发病率为31.80/105。2003年CH的实验室检测方法由放免法改为时间分辨荧光免疫分析法,此可能为北京市CH发病率上升的主要原因。结论 1994-2011年北京市CH发病率呈明显上升趋势。
Objective To analyze the incidence and trend of congenital hypothyroidism (CH) in Beijing and provide a scientific basis for the rational formulation of strategies and measures for CH prevention and care. Methods Using the 1994-2011 data of screening neonatal diseases in Beijing for descriptive analysis and statistical inference. Results The incidence of CH in Beijing increased year by year in 18 years with an average incidence of 31.85 / 105. In 2003, the laboratory test method of CH was changed from radioimmunotherapy to time-resolved fluorescence immunoassay, which may be one of the causes of CH in Beijing The main reason for the rise in rates. Conclusion The incidence of CH in Beijing from 1994 to 2011 showed a clear upward trend.