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慢性中耳炎时,常采用局部给药法进行治疗。近年来,由于抗菌素使用较为普遍等因素,使多数慢性中耳炎病例的鼓室内壁粘膜病变较轻,因而滴入耳内之药液易人上、下鼓室并直达两窗。通过药物的理化作用即可损害内耳。药物进入内耳的途径为:(1)蜗窗:作者等将消毒剂洗必太注入动物鼓室内2～4小时后,可在蜗窗内皮层上发现附着物;(2)前庭窗:实验证明,与蜗窗比较,药液甚少能通过前庭窗;(3)神经孔:电镜观察发现,在神经纤维通过骨螺旋板的出口附近,其鼓阶侧上皮细胞间有间隙存在,使
Chronic otitis media, often using local administration method for treatment. In recent years, the use of antibiotics is more common and other factors, the majority of cases of chronic otitis media tympanic mucosal lesion lesser, so drip into the ear of the liquid to the upper and lower tympanic and direct two windows. Physical and chemical effects through the drug can damage the inner ear. Drugs into the inner ear as follows: (1) the snail: the author will be disinfected chlorhexidine injection into the animal drum 2 to 4 hours later, the cortex can be found in the cortex attachment; (2) vestibular window: experimental evidence , Compared with the snail window, the solution rarely through the vestibular window; (3) neural pore: electron microscopy found that in the nerve fiber near the exit through the bone spiral plate, there is a gap between the scala tympani epithelial cells