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目的：利用自制含氯霉素、甲硝唑等药物的控释系统，对实验家兔的血药浓度、药物抗菌活性和家兔根管、尖周组织的病理观察，为今后临床应用提供理论和实验依据。方法：应用组织病理观察和液相色谱分析技术。结果：用ＨＰＬＣ法得出实验用家兔血药浓度和抗菌活性均为阴性，根管及尖周组织病理切片无特殊表现。结论：自制控释系统是一种无毒、无副作用、有效的根管治疗药物剂型，可进行临床应用。
OBJECTIVE: To provide a theoretical basis for the future clinical application of the controlled release system of chloramphenicol, metronidazole and other drugs by self-made in rabbits. The blood concentration of the rabbits, the antibacterial activity of the drug and the pathological observation of the canine and apical tissues in rabbits And experimental basis. Methods: The application of histopathology and liquid chromatography techniques. Results: The HPLC method was used to determine the experimental rabbit blood concentration and antibacterial activity were negative, root canal and perineal tissue biopsy showed no special performance. Conclusion: Self-controlled release system is a non-toxic, no side effects, effective root canal treatment of drug formulations, for clinical applications.