目的探讨超敏C反应蛋白(high-sensitivity C-reactive protein,h-s CRP)水平及rs1205基因多态性与脑梗死(cerebral infarction,CI)的相关性。方法采用病例对照研究对105例脑梗死患者和121例健康对照者进行研究;采用免疫透射比浊法测定h-s CRP、用多聚酶链式反应(polymerase chain reaction,PCR)和限制性片段长度多态性测定rs 1205基因多态性;患者入院后立即用美国国立卫生院神经功能缺损评分(National Institutes of Health Stroke Scale,NIHSS)对其进行神经功能测评。结果脑梗死组与对照组rs1205基因型频率分布无显著性差异(P>0.05)。重型脑梗死患者的h-s CRP水平显著高于轻、中度组(P均<0.05),但rs1205与脑梗死病情无关联。结论 h-s CRP水平与脑梗死严重程度相关。rs1205基因多态性与脑梗死无关联。 Objective To investigate the relationship between high-sensitivity C-reactive protein (h-s CRP) level and rs1205 gene polymorphism and cerebral infarction (CI). Methods A case-control study was conducted on 105 patients with cerebral infarction and 121 healthy controls. The hs CRP was measured by immunoturbidimetric assay. The expression of hs CRP was detected by polymerase chain reaction (PCR) and restriction fragment length polymorphism The rs 1205 gene polymorphism was determined; patients were assessed for neurological function immediately after admission with the National Institutes of Health Stroke Scale (NIHSS). Results There was no significant difference in rs1205 genotype between cerebral infarction group and control group (P> 0.05). The levels of h-s CRP in patients with severe cerebral infarction were significantly higher than those in mild and moderate groups (all P <0.05), but there was no correlation between rs1205 and the severity of cerebral infarction. Conclusion The level of h-s CRP is related to the severity of cerebral infarction. rs1205 gene polymorphism and cerebral infarction no correlation.