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目的比较四联与标准三联疗法在结节性胃炎中根除幽门螺杆菌(Helicobacter pylori,HP)率的临床疗效。方法依据临床症状、胃镜所见、病理诊断、幽门螺杆菌检测诊断为结节性胃炎的86例患者随机分为两组。治疗组(四联疗法)方案:埃索美拉唑镁20 mg,2次/d+枸橼酸铋钾220 mg,4次/d+阿莫西林1.0,2次/d+克拉霉素0.5,2次/d治疗2周,对照组(标准三联疗法)方案:埃索美拉唑镁20 mg,2次/d+阿莫西林1.0,2次/d+克拉霉素0.5,2次/d治疗2周。所有患者于用药结束后至少4周复查胃镜、HP快速尿素酶试验及14C-尿素呼气试验。对两组进行卡方检验。结果治疗组、对照组两组HP根除率分别为:88.4%、69.8%,(P<0.05)两组间差别有统计学意义。结论四联疗法较标准三联疗法治疗结节性胃炎有较高的HP根除率。
Objective To compare the clinical efficacy of quadruple and standard triple therapy in the eradication of Helicobacter pylori (HP) in nodular gastritis. Methods Based on clinical symptoms, gastroscopy, pathological diagnosis, diagnosis of Helicobacter pylori diagnosis of nodular gastritis in 86 patients were randomly divided into two groups. Treatment group (quadruple therapy) program: esomeprazole magnesium 20 mg, 2 times / d + bismuth potassium citrate 220 mg, 4 times / d + amoxicillin 1.0,2 times / d + clarithromycin 0.5,2 / d treatment for 2 weeks, the control group (standard triple therapy) program: esomeprazole magnesium 20 mg, 2 times / d + amoxicillin 1.0,2 times / d + clarithromycin 0.5,2 times / d treatment for 2 weeks. All patients underwent endoscopy, HP rapid urease test and 14C-urea breath test at least 4 weeks after the end of medication. Chi-square test was performed on both groups. Results The eradication rates of HP in treatment group and control group were 88.4% and 69.8%, respectively (P <0.05). There was significant difference between the two groups. Conclusions Quadruple therapy has a higher HP eradication rate than standard triple therapy for nodular gastritis.