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随着临床真菌感染的发病率、耐药率日益升高,真菌致病及耐药机制的分子生物学研究受到广泛关注。该项目对重要疑难真菌病的诊治,致病真菌致病机理、遗传多态性、体外药敏特征及耐药机制,对少见疑难皮肤病的诊治等方面进行了系列研究。在真菌病的诊疗方面,国际首次发现指甲隐球菌引起人类脑膜炎。该菌种
With the incidence of clinical fungal infections, drug resistance is increasing, molecular mechanisms of fungal pathogenesis and resistance of molecular biology has received widespread attention. The project conducted a series of researches on the diagnosis and treatment of important difficult fungal diseases, the pathogenic mechanism of pathogenic fungi, genetic polymorphisms, drug susceptibility characteristics and drug resistance mechanism in vitro, diagnosis and treatment of rare and difficult skin diseases. In the diagnosis and treatment of fungal diseases, the first time in the world that Cryptococcus neoformans caused human meningitis. The strain