目的：观察米非司酮配伍米索前列醇终止孕１０～１６周妊娠的临床效果。方法：对２５６例孕１０～１６周妇女，随机分为两组，一组（１４４例）给予米非司酮口服（为米索组），另一组（１１２例）给予利凡诺羊膜腔注射（为利凡诺组），观察两组的有效流产率、钳刮率及平均出血量。结果：两组有效流产率分别为９３７５％和７６７９％；钳刮率为０和１７５８％（Ｐ＜０００１）。平均出血量分别为７１１８±５５７５ｍＬ和１０１３４±７３９２ｍｌ（Ｐ＜００１）。结论：米非司酮配伍米索前列醇终止孕１０～１６周妊娠优于传统的利凡诺，可明显减少钳刮和流产出血量，作为一种非侵入性方法，简便、安全、有效，值得推广。 Objective: To observe the clinical effect of mifepristone and misoprostol to terminate the pregnancy of 10 ~ 16 weeks. Methods: A total of 256 pregnant women aged 10-16 weeks were randomly divided into two groups: one group (144 cases) received oral mifepristone (misoprostol group) and the other group (112 cases) received rivanol amnion Injection (for rivanol group), the effective abortion rate, clamp curettage rate and mean blood loss were observed in both groups. Results: The effective abortion rates of the two groups were 9375% and 7679% respectively. The curettage rates were 0 and 1758% (P <0001). The average amount of bleeding was 71.18 ± 5575 mL and 10134 ± 7392 ml, respectively (P <001). Conclusion: Mifepristone combined with misoprostol is superior to the traditional rivanol in terminating pregnancies of 10-16 weeks’ gestation, which can significantly reduce the forceps and blood loss. As a noninvasive method, it is simple, safe and effective, Worth promoting.