自身免疫性疾病是一类机体对自身抗原发生免疫反应而导致自身组织损害的疾病,为机体免疫应答失控的表征。传统的化药等通常仅缓解疼痛或减轻症状,达不到明显的治疗效果。随着生命科学的发展,机体各信号通路、靶点蛋白的研究深入,以及近年来抗体药物的研究进展和技术成熟,单抗及Fc融合蛋白等蛋白药物的使用成为当前治疗该类疾病的热点。目前上市的相关产品已有十余种,产品主要特异性靶向TNF,部分IL家族及其他一些靶标蛋白。 Autoimmune diseases are a class of diseases in which the body’s immune response to its own antigens causes damage to its own tissues and is indicative of uncontrolled immune response in the body. Traditional chemical drugs usually only relieve pain or reduce symptoms, failing to reach obvious therapeutic effect. With the development of life science, the body’s various signaling pathways, the study of target proteins and the progress of antibody research and technology maturation in recent years, the use of protein drugs such as monoclonal antibodies and Fc fusion proteins has become a hot spot in the current treatment of such diseases . Currently there are more than 10 kinds of related products listed, the product mainly targeted specifically TNF, some IL family and some other target protein.