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目的:分析女性绝经前后性激素与血脂水平的变化,指导围绝经期的女性保健。方法:选择围绝经期女性90例,并分为绝经前组(45例)和绝经后组(45例),分析两组女性的性激素与血脂水平的变化。结果:绝经后雌二醇(E2)水平显著下降,孕酮(P)、卵泡刺激素(FSH)和黄体生成素(LH)水平显著上升,与绝经前相比,差异具有统计学意义(P<0.05,P<0.01);绝经后睾酮(T)水平略有上升,与绝经前相比差异无统计学意义(P>0.05);绝经后甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)和脂蛋白-α(LP-α)水平显著上升,与绝经前相比差异具有统计学意义(P<0.05,P<0.01);绝经后高密度脂蛋白胆固醇(HDL-C)水平有所下降,与绝经前相比差异无统计学意义(P>0.05)。结论:女性围绝经期应定期检查性激素与血脂,出现异常时应及早采取雌激素替代治疗和降脂治疗,并加强日常锻炼,合理饮食,以保障围绝经期女性身心健康。
OBJECTIVE: To analyze the changes of sex hormones and blood lipids in women before and after menopause to guide the women’s health in the perimenopausal period. Methods: 90 cases of perimenopausal women were selected and divided into premenopausal group (45 cases) and postmenopausal group (45 cases). The changes of sex hormones and blood lipids in both groups were analyzed. Results: The level of estradiol (E2) in postmenopausal women decreased significantly and the level of progesterone (P), follicle stimulating hormone (FSH) and luteinizing hormone (LH) increased significantly compared with premenopausal women (P (P <0.05, P <0.01); postmenopausal testosterone (T) levels increased slightly, with no significant difference compared with premenopausal women (P> 0.05); postmenopausal TG, TC, The level of LDL-C and LP-α increased significantly (P <0.05, P <0.01), the difference of postmenopausal high-density lipoprotein Cholesterol (HDL-C) levels decreased, compared with pre-menopausal differences was not statistically significant (P> 0.05). CONCLUSIONS: Sexual hormones and lipids should be regularly examined in perimenopausal women. If abnormalities occur, estrogen replacement therapy and lipid-lowering therapy should be taken as soon as possible. Daily exercise and diet should be strengthened to ensure the perimenopausal women’s physical and mental health.