在这个结构中,特别引人注意的是关于环醇部分形成的问题。按照Hofmann的合成,环醇部分的N及C-OH之间的键是由一个酰基化的胡椒酮(Ⅱ)通过多步反应而来的,但我们认为具有环醇结构的化合物如(Ⅲ)也可同样由环氧三肽(Ⅳ)通过跨环反应而来。在我们工作的进行中,见到了一些报导,系统的研究N-(α-或β-hydroxyacyllactam) Of particular note in this structure is the problem with the formation of cyclic alcohols. According to Hofmann’s synthesis, the bond between N and C-OH of the cyclic alcohol moiety is obtained by an acylated piperonyl ketone (II) by a multistep reaction, but we believe that compounds having a cyclic alcohol structure such as (III) It is also possible by the cross-ring reaction of the epoxy tripeptide (IV). In the course of our work, we have seen some reports on the systematic study of N- (α- or β-hydroxyacyllactam)