论文部分内容阅读
目的探讨电刺激小脑顶核(FNS)对帕金森患者的运动症状及抑郁症状的影响。方法将105例伴随抑郁症状的帕金森病(PD)患者随机分为FNS+美多巴组(药物+刺激组)、单纯刺激组(刺激组)、单纯美多巴组(药物组),每组35例。根据分组,对需要刺激的患者予以FNS治疗,每次通电30min,每日治疗1次,连续治疗30d。需要服药的患者仍按常规服用美多巴。所有患者治疗期间美多巴用量不变。于治疗前、后予以改良Webster评分及汉密尔顿抑郁分级量表(HAMD)评分。结果 FNS治疗后,药物+刺激组患者运动症状有所改善,抑郁症状有所减轻,Webster和HAMD评分均减少,其差异具有统计学意义(P<0.05);单纯刺激组运动症状改善不明显,但抑郁症状有所减轻,其差异具有统计学意义(P<0.05);单纯药物组则无明显改变。结论电刺激小脑顶核作为康复疗法,在改善帕金森病患者运动症状和抑郁症状方面均有疗效,是一种行之有效的疗法,适用于PD患者的康复治疗。
Objective To investigate the effects of electrical stimulation of cerebellar fastigial nucleus (FNS) on motor symptoms and depressive symptoms in Parkinson’s disease. Methods One hundred and fifty patients with Parkinson’s disease (PD) accompanied by depressive symptoms were randomly divided into FNS + meduoba group (drug + stimulation group), simple stimulation group (stimulation group), meduridin group (drug group) 35 cases. According to grouping, need to stimulate the patients to be FNS treatment, each power 30min, daily treatment 1, continuous treatment 30d. Patients taking medications are still taking methadjins as usual. Medobal consumption unchanged during all patients. The modified Webster score and the Hamilton Depression Rating Scale (HAMD) score were used before and after treatment. Results After FNS treatment, the symptom of the patients in the drug + stimulation group was improved, the depressive symptoms were relieved, the scores of Webster and HAMD were decreased, the difference was statistically significant (P <0.05); the motor symptoms of the simple stimulation group did not improve obviously, However, the symptoms of depression were relieved, the difference was statistically significant (P <0.05); no significant change was found in the simple drug group. Conclusion Electrical stimulation of the cerebellar fastigial nucleus as a rehabilitation therapy is effective in improving motor symptoms and depressive symptoms in patients with Parkinson’s disease and is an effective therapy for the rehabilitation of PD patients.