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目的探讨胸腺五肽联合干扰素治疗尖锐湿疣的临床效果。方法 130例尖锐湿疣患者按随机数字表法分为治疗组65例和对照组65例。治疗组用二氧化碳激光把尖锐湿疣去除后,肌注胸腺五肽注射液1 mg,隔日1次,肌注重组人干扰素α-2b 300万U,每周2次,均连用4周。对照组用二氧化碳激光去除尖锐湿疣疣体后,未使用任何免疫药物治疗。两组治疗后12周观察疗效。结果治疗组治愈率为90.77%(59/65),无效4例(6.15%),复发率2例(3.08%);对照组分别为70.77%(46/65)、16.92%(11/65)、12.31%(8/65)。治疗组疗效明显优于对照组(P<0.05)。治疗组肌注重组人干扰素α-2b后患者出现1~2次低热25例(38.5%),疲倦感觉2例(3.0%),无需处理。两组均未发生其他明显不良反应。结论胸腺五肽与干扰素治疗尖锐湿疣明显优于单纯用二氧化碳激光,且能提高疗效,降低复发率。
Objective To investigate the clinical effect of thymopentin combined with interferon on condyloma acuminatum. Methods One hundred and thirty patients with condyloma acuminatum were divided into treatment group (n = 65) and control group (n = 65) according to random number table. Treatment group with carbon dioxide laser to remove genital warts, intramuscular injection of thymopentin 1 mg, once every other day, intramuscular group of human interferon α-2b 3 million U, twice a week, were used for 4 weeks. The control group with carbon dioxide laser removal of condyloma acuminatum, did not use any immunotherapy. The two groups were observed after 12 weeks of treatment. Results The cure rate in treatment group was 90.77% (59/65), 4 cases (6.15%) were ineffective, and the recurrence rate was 2 cases (3.08%). The control group were 70.77% (46/65) and 16.92% (11/65) , 12.31% (8/65). The treatment group was significantly better than the control group (P <0.05). In the treatment group, there were 25 cases (38.5%) with mild fever 1-2 times and 2 cases (3.0%) with unpleasant feeling after intramuscular injection of human interferon α-2b, without treatment. No other obvious adverse reactions occurred in both groups. Conclusion Thymopentin and interferon treatment of genital warts was significantly better than that of carbon dioxide laser alone, and can improve the curative effect and reduce the recurrence rate.