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目的 :探讨血清急性时相蛋白在胃癌中发生、发展中的作用及临床意义。方法 :手术前用Array特定蛋白分析系统 ,全自动速率散射比浊法检测 12 0例胃癌患者的C 反应蛋白 (CRP)、α1 抗糜蛋白 (AT)和α 酸性糖蛋白 (α AG)水平。结果 :CRP、α1 AT和α AG的阳性表达明显高于良性胃病组 (P <0 0 1)。与肿瘤患者的年龄、性别、部位及细胞的分化程度无明显相关 (P >0 0 5 ) ;侵犯胃壁浆膜及肌层组显著高于粘膜及粘膜下层组 (P <0 0 1) ;有淋巴结转移组明显高于无淋巴结转移组 (P <0 0 1) ;Ⅲ、Ⅳ期显著高于Ⅰ、Ⅱ期 (P <0 0 1)。随访表明其阳性组复发率 ( 82 3%、87 5 %、88 2 % )与阴性组 ( 30 2 %、2 9 6 %、2 7 9% )比较 ,差异有显著性 (P <0 0 1)。结论 :CRP、α1 AT和α AG是胃癌发展过程中的一种有价值的病理指标 ,也可作为判断胃癌预后的指标之一。
Objective: To investigate the role of serum acute phase protein in gastric carcinogenesis and development and its clinical significance. Methods: Prior to surgery, C-reactive protein (CRP), α1-antitumor protein (AT) and α-acid glycoprotein (αAG) were detected by Array-specific protein analysis system and automated rate nephelometry in 120 patients with gastric cancer. Results: The positive expression of CRP, α1 AT and α AG was significantly higher than that of benign gastric disease group (P <0.01). There was no significant correlation between tumor invasion and tumor differentiation (P> 0.05). The invasion to gastric mucosa and muscular layer was significantly higher than that from mucosa and submucosa (P <0.01) Lymph node metastasis was significantly higher than those without lymph node metastasis (P <0.01); stage Ⅲ and Ⅳ were significantly higher than those in stage Ⅰ and Ⅱ (P <0.01). The follow-up showed that the recurrence rate of the positive group (82.3%, 87.5%, 88.2%) was significantly lower than that of the negative group (30.2%, 296%, 279%) (P <0.01 ). CONCLUSION: CRP, α1 AT and α AG are valuable pathological markers in the development of gastric cancer and may be used as one of the indicators to judge the prognosis of gastric cancer.