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目的分析上海市浦东新区女性原发性乳腺癌发病、死亡及生存情况。方法利用2002-2010年浦东新区女性居民原发性乳腺癌的登记资料,分年龄组计算发病率、死亡率,用世界标准人口计算标化率,采用对数直线回归法估算发病率及死亡率的年度变化百分比(annual percent change,APC),应用Life-Tables计算患者1~5年生存率,用KaplanMeier法分析不同TNM分期和是否知晓病情的乳腺癌患者的生存情况。结果 2002-2010年上海市浦东新区女性原发性乳腺癌新发患者5 990例,中位发病年龄53.92岁,粗发病率为51.69/10万,标化发病率为30.49/10万;因乳腺癌死亡病例1 686例,粗死亡率为14.55/10万,标化死亡率为8.13/10万。乳腺癌年龄别发病率高峰出现在45~49岁,高年龄段(>60岁)发病率呈逐渐下降型。乳腺癌患者1~5年生存率分别为95.63%、91.61%、87.77%、84.32%和81.85%,不同TNM期别患者生存时间差异有统计学意义,早期患者(0~Ⅰ期)1~5年生存率高于中晚期患者(u(0~Ⅰ)期、Ⅱ期=25.63,u(0~Ⅰ)期、Ⅲ期=213.18,u(0~Ⅰ)期、Ⅳ期=697.57,P均<0.001)。对较早期患者进行疾病告知有助于提高其生存率(u(0~Ⅰ)期=19.65,uⅡ期=7.67,P<0.01)。结论乳腺癌是威胁浦东新区女性健康的重要恶性肿瘤,其发病高峰出现在45~49岁,肿瘤早发现及对于早期患者进行疾病的告知可改善其预后。
Objective To analyze the incidence, mortality and survival of primary breast cancer in Shanghai Pudong New Area. Methods According to the registration data of female primary breast cancer from 2002 to 2010 in Pudong New Area, the morbidity and mortality were calculated by age group. The standardization rate was calculated by world standard population, and the incidence and mortality were estimated by logarithm linear regression Annual percent change (APC). Life-Tables were used to calculate the 1- to 5-year survival rate of patients. Kaplan-Meier method was used to analyze the survival of breast cancer patients with different TNM staging and whether they were aware of the disease. Results From 2002 to 2010, 5,990 new cases of primary breast cancer were reported in Shanghai Pudong New Area. The median age of onset was 53.92 years old. The crude incidence rate was 51.69 / 100000. The standardized incidence rate was 30.49 / There were 1 686 cancer deaths, with a crude death rate of 14.55 / 100,000 and a standardized mortality rate of 8.13 / 100,000. The age-specific incidence of breast cancer in 45 to 49 years of age, the incidence of higher age (> 60 years) showed a gradual decline. The 1- 5-year survival rates of patients with breast cancer were 95.63%, 91.61%, 87.77%, 84.32% and 81.85%, respectively. There were significant differences in the survival time between different TNM patients and early patients (stage 0 to 1) The annual survival rate was higher than that in the advanced stage (u (0 ~ Ⅰ), Ⅱ = 25.63, u (0 ~ Ⅰ), Ⅲ = 213.18, u <0.001). Disease notification to earlier patients helped to improve their survival rate (u (0 ~ Ⅰ) = 19.65, uⅡ = 7.67, P <0.01). Conclusion Breast cancer is an important malignant tumor which threatens the health of women in Pudong New District. The peak incidence of this disease is 45-49 years old. The early detection of tumor and the notification of disease in early patients can improve its prognosis.