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舒更葡糖钠是Merck公司开发的用于罗库溴铵或维库溴铵等神经肌肉麻醉剂(NMBA,也称作肌肉松弛药)诱导产生的神经肌肉麻醉反转剂。神经肌肉麻醉剂的反转试剂常给予外科手术或一段时间的强化治疗结束时的病人,来帮助其恢复肌肉功能。常用的神经肌肉麻醉剂的反转试剂是乙酰胆碱酯酶抑制剂(ACh E),如依酚氯铵、新斯的明、溴吡斯的明,不适合去极化神经肌肉麻醉剂如琥珀酰胆碱的反转。本文提供了一种制备舒更葡糖钠中间体的方法,本方法工艺过程简单、高收率、高纯度、无污染,适合工业化生产。
Sodium thymidine is a neuromuscular reversal agent developed by Merck for the induction of neuromuscular blockade (NMBA, also known as muscle relaxant), such as rocuronium or vecuronium. Reversal agents for neuromuscular anesthetics are often given to patients at the end of surgery or intensive treatment over a period of time to help them recover muscle function. Reversal reagents for commonly used neuromuscular anesthetics are acetylcholinesterase inhibitors (ACh E), such as epoetin, neostigmine, and pyridostigmine, which are not suitable for depolarizing neuromuscular anesthetics such as succinylcholine The reverse. This invention provides a method for preparing sodium glucosamine succinate. The method has the advantages of simple process, high yield, high purity and no pollution, and is suitable for industrialized production.