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应用鸡卵清蛋白致敏和刺激小鼠复制过敏性气道炎症反应模型研究血小板激活因子选择性拮抗剂ＹＭ－２６４对抗原引起气道嗜酸性粒细胞（ＥＯＳ）浸润的影响。结果发现，正常小鼠支气管肺泡灌洗液（ＢＡＬＦ）中未见到ＥＯＳ；致敏小鼠给予抗原多次反复吸入刺激后，ＢＡＬＦ中ＥＯＳ急剧增多。在ＹＭ－２６４治疗各组中，ＹＭ－２６４的不同剂量分别导致ＥＯＳ数下降２７．０％、４８．２％及６７．９％。还发现ＹＭ－２６４抑制ＥＯＳ对气道的浸润伴随着白细胞介素（ＩＬ）－５水平的明显下降。提示ＹＭ－２６４通过抑制ＩＬ－５的产生从而抑制了ＥＯＳ在气道的聚集。
To investigate the effect of platelet activating factor selective antagonist YM-264 on antigen-induced airway eosinophil (EOS) infiltration induced by chicken ovalbumin sensitization and stimulation of mouse replication allergic airway inflammation. The results showed that normal mice bronchoalveolar lavage fluid (BALF) did not see EOS; sensitized mice given repeated inhalation of antigen stimulation, BALF EOS sharp increase. Different doses of YM-264 in each group treated with YM-264 resulted in a 27.0%, 48.2% and 67.9% decrease in the number of EOS, respectively. It has also been found that YM-264 inhibits airway infiltration of EOS with a significant decrease in interleukin (IL) -5 levels. It is suggested that YM-264 inhibits the accumulation of EOS in the airway by inhibiting the production of IL-5.