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目的 :探讨类风湿性关节炎 (RA)患者血浆血小板膜颗粒蛋白 (GMP -14 0 )的变化及意义.方法 :用ELISA法检测 42例RA患者和 15例正常人血浆血小板GMP -14 0的含量 ,同时检测血小板计数 (BPC)及血沉 (ESR).结果 :活动期RA(n=2 4)患者血浆血小板膜GMP -14 0含量 (5 8 32± 8 18μg/L)明显高于缓解期RA患者 (17 18± 2 5 8μg/L ,n=18)和正常对照组 (15 74± 2 33μg/L ,n =15 ) (P均 0 0 5 ).活动期RA患者中有 15例进行了治疗前后的观察 ,经治疗RA病情得到控制后 ,GMP -14 0明显下降 ,接近正常.活动期RA患者血小板GMP -14 0含量与BPC呈正相关 (r=0 797,P“,”Objective:To explore the significane of changes in the quantity of platelet α-granule menbrane protein-140(GMP-140) in patients with rheumatoid arthritis(RA).Methods:The quantity of platelet GMP-140 in plasma were detected by ELISA in 42 cases of RA and 15 normal controls. The blood platelet count(BPC) and erythrocyte sedimentation rate(ESR) were measure too.Results:The quantity of plasma platelet GMP-140 (58 32±8 18ug/L, n=24) in active RA group was significantly higher than that in remissive RA group (17 18±2 58ug/L, n=18) and normal controls (15.74±2.33ug/L,n=15), (P0 05). The level of plasma platelet GMP-140 in 15 cases of active RA was obsered before or after treatment. After treatment, the plasma platelet GMP-140 had obviously reduced. There was a correlation between a level of plasma platelet GMP-140 and BPC(r=0.797, P<0 01), and also acorretation between a level of plasma platelet GNP-140 and ESR(r=0 459,P<0 05).Conclusion:The patients of RA had not only changes of platelet quantify, but also platelet activation.There was correlation between paltelet activation and activty of disease,and may be a second change.In clinic,the treatment of RA is key the preventing platelet activation and thrombosis formation.