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西咪替丁(Cimetidine,下称CMD)系组胺H_2受体拮抗剂,是消化性溃疡,卓—艾氏综合征的常用药。近年来,许多研究表明,该药尚有调节免疫、抗病毒及抗癌等新功能,现介绍如下。 1 CMD在过敏性疾病中的应用 1.1 治疗过敏性紫癜 朱氏曾报道31例过敏性紫癜患者,其中65％在应用糖皮质激素无效后改用本药静滴,待紫癜消退后予以口服15天,总有效率达97％,且无不良反应。 1.2 预防上消化道出血患者输血过敏反应的发生 袁氏等报道,CMD既有利于止血,又可望减少输血过敏反应,其发热、皮疹,搔痒等过敏反应发生率显著降低。 1.3 治疗嗜酸性筋膜炎 徐氏曾收治2例嗜酸性筋膜炎,其中1例经强的松治疗无效后改用本药,治疗半年后,病变皮肤基本恢复正常。
Cimetidine (Cimetidine, hereinafter referred to as CMD) is a histamine H 2 receptor antagonist, peptic ulcer, Zhuo - Ehrlich syndrome commonly used drugs. In recent years, many studies have shown that this medicine still has some new functions of regulating immunity, anti-virus and anti-cancer. The introduction is as follows. 1 CMD in the application of allergic diseases 1.1 Treatment of allergic purpura Zhu reported 31 cases of allergic purpura patients, of which 65% after the application of glucocorticoid ineffective use of the drug infusion until after the purpura subsided to oral 15 days , The total efficiency of 97%, and no adverse reactions. 1.2 Prevention of upper gastrointestinal bleeding in patients with transfusion allergic reactions Yuan reported that both CMD is conducive to hemostasis, but also reduce the transfusion allergic reaction, the fever, rash, itching and other allergic reactions was significantly reduced. 1.3 Treatment of eosinophilic fasciitis Tsui had received two cases of eosinophilic fasciitis, of which 1 case of prednisone treatment after the switch to the drug, six months after treatment, the lesion returned to normal.