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目的观察低分子右旋糖酐联合多巴胺、速尿静滴治疗肝硬化腹水的疗效。方法将陕西省安康职业技术学院附属医院内科2001年6月至2005年10月收治的肝硬化并发腹水者102例随机分为治疗组和对照组。治疗组51例,用低分子右旋糖酐联合多巴胺、速尿静滴,口服安体舒通治疗;对照组51例,用口服速尿加安体舒通治疗,2组均常规护肝治疗。观察2组的腹水消退平均时间和有效率。结果 2组比较,治疗有效率及腹水完全消退平均时间差异具有显著性意义(P<0.01)。2组皆未见明显副反应。结论低分子右旋糖酐联合多巴胺、速尿静滴治疗肝硬化腹水的疗效优于一般治疗方法,值得临床进一步推广。
Objective To observe the effect of low molecular dextran combined with dopamine and furosemide in the treatment of ascites due to cirrhosis. Methods A total of 102 patients with cirrhosis complicated with ascites admitted from June 2001 to October 2005 in Affiliated Hospital of Ankang Vocational and Technical College of Shaanxi Province were randomly divided into treatment group and control group. Treatment group of 51 cases, with low molecular weight dextran combined with dopamine, furosemide drip, oral spironolactone treatment; control group of 51 cases, with oral furosemide plus spironolactone treatment, two groups are routine liver protection treatment. The average time and effective rate of ascites in two groups were observed. Results The difference between the two groups in the mean effective rate of treatment and the complete regression of ascites was significant (P <0.01). No obvious side effects were observed in both groups. Conclusion Low molecular dextran combined with dopamine and furosemide intravenous drip in the treatment of ascites due to cirrhosis is superior to the general treatment, which is worth further promotion in clinic.