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目的对比不同内科方法治疗进展期非小细胞肺癌(NSCLC)的临床疗效。方法选取武汉市黄陂区人民医院2012年12月—2014年4月收治的进展期NSCLC患者52例,根据治疗方法和患者自身情况分为3组:单纯化疗组15例,序贯治疗组21例,姑息治疗组16例。单纯化疗组给予NP方案、GP方案、TP方案、AP方案中一种方案治疗;序贯治疗组化疗方法同单纯化疗组,在化疗结束2周后开始使用吉非替尼治疗;姑息治疗组给予最佳的对症支持治疗,比较3组的疗效。结果序贯治疗组和单纯化疗组的疾病控制率高于姑息治疗组,序贯治疗组疾病控制率高于单纯化疗组,差异有统计学意义(P<0.05);序贯治疗组中位生存期为10.3个月、1年生存率为52.38%,单纯化疗组分别为7.6个月、33.33%,姑息治疗组分别为3.2个月、12.50%;序贯治疗组和单纯治疗组的中位生存期长于姑息治疗组、1年生存率高于姑息治疗组,序贯治疗组中位生存期长于单纯化疗组、1年生存率高于单纯化疗组,差异有统计学意义(P<0.05)。结论序贯治疗方案治疗进展期NSCLC的疗效良好。
Objective To compare the clinical effects of different medical methods in the treatment of advanced non-small cell lung cancer (NSCLC). Methods Fifty-two patients with advanced NSCLC who were treated in Huangpi District People’s Hospital of Wuhan from December 2012 to April 2014 were divided into three groups according to the treatment method and the patient’s own condition: 15 patients in the chemotherapy alone group and 21 patients in the sequential therapy group , Palliative treatment group of 16 cases. The chemotherapy group was given NP regimen, GP regimen, TP regimen and AP regimen. The sequential chemotherapy regimen was the same as that of the simple chemotherapy regimen, and gefitinib was started 2 weeks after the end of chemotherapy. The palliative treatment group The best symptomatic supportive treatment, the efficacy of the three groups were compared. Results The sequential control group and the chemotherapy alone group had a higher rate of disease control than the palliative group. The sequential control group had a higher rate of disease control than the chemotherapy alone group (P <0.05), and the median survival rate The median survival time was 10.3 months. The 1-year survival rate was 52.38%. The chemotherapy alone group was 7.6 months and 33.33% respectively, while the palliative treatment group was 3.2 months and 12.50% respectively. The median survival rate between the sequential therapy group and the simple therapy group The median survival time of the sequential therapy group was longer than that of the chemotherapy alone group, and the one-year survival rate was higher than that of the chemotherapy alone group (P <0.05). Conclusions Sequential regimens are effective in the treatment of advanced NSCLC.